LLM Research - Papers: Safety

LLM Research - Papers: Safety

Inference// LLM// Safety// Speech

Polaris 6: the first healthcare model with bedside intuition

Built on the only model benchmarked safe enough for patient-facing care, Polaris 6.0 Ultra brings a 7.4-trillion-parameter safety constellation, a

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What the Reranker Sees: Multi-Aspect Page Annotation for Long-Document Multimodal Question Answering

Helps AI find the right pages in long documents by giving it richer clues than raw text alone.

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Case Study: Improving Pre-Charting for Medicare Wellness Visits at OhioHealth

OhioHealth partnered with Hippocratic AI to pilot a generative AI healthcare agent for pre-charting Medicare Wellness Visits, testing whether AI

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From Sound to Symptom: Real-Time Respiratory Signal Understanding for Conversational Healthcare Agents

Teaches voice AI to hear a patient’s cough as a clinical signal instead of background noise.

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Population-Scale Functional Fall-Risk Indicator Assessment in Medicare Annual Wellness Visits Using Conversational AI

Nearly one in three older adults who reported no falls in the past year still showed two or more functional

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Therapeutic Inertia in Pharmacologic Dose Optimization: Prevalence, Clinical Consequences, and Economic Burden Across Sixteen Chronic Conditions

Failure to titrate medications to guideline-recommended target doses is widespread across sixteen chronic conditions and carries substantial clinical and economic

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Hidden Functional Decline: How Conversational Voice AI Detects Early Mobility and ADL Impairment in Older Adults with High Self-Rated Health

Nearly half of the older adults who described their own health as good or better showed two or more mobility

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On-Policy Self-Distillation for Reinforcement Learning in LLM Post-Training: A Unified Framework and Survey

A unified framework for understanding on-policy self-distillation as dense teacher-guided supervision in RL-based LLM post-training.

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TRADE: Transducer-Augmented Decoder for Speech LLM

Most speech AI models can't respond while you're still talking — they lose track of the audio as it arrives,

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Inference// Speech

Voice, Safety, and Latency: Building AI for Healthcare Conversations (Part 2)

How we engineered a voice stack that answers in under a second — and feels human doing it.

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Hippocratic AI Launches Polaris 5.0: The First Evidence- based AI for Healthcare Proven to Outperform Major Frontier Models on Critical Medical Tasks and Safety

New Skills and Features for Healthcare Introduced: Built on more than 180m real patient interactions, validated by U.S.-licensed clinicians and

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Agents’ Last Exam

Tests whether AI agents can actually do real, paid professional work — not just pass toy benchmarks.

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Inference// Safety// Speech

Voice, Safety, and Latency: Building AI for Healthcare Conversations (Part 1)

Why holding a natural healthcare conversation is one of the hardest problems in real-time AI.

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A Simple Plug-in for Improving Eviction-Based KV Cache Compression

A simple inference add-on that lets AI models handle long conversations with far less memory.

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Generative Artificial Intelligence-Driven Voice Assistance for Patient Education in Ophthalmology

Patients and eye doctors gave high marks to a voice AI that teaches patients about eye-injection treatment.

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Crafting Reversible SFT Behaviors in Large Language Models

A way to install a new behavior in an AI model — and cleanly switch it off later.

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Transforming Healthcare AI Education Through Micro-Learning: A Novel Partnership Model for Nursing Workforce Development

An academic-industry partnership delivering 11 short AI courses to 478 nursing students and faculty produced measurable knowledge gains alongside satisfaction

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Benchmarks// LLM// Safety

Hippocratic AI Launches Polaris 5.0: The First Evidence-Based AI for Healthcare Proven to Outperform Major Frontier Models

Announcing Polaris 5.0 — built on 180M+ real patient interactions and benchmarked against every major frontier model.

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RaMP: Runtime-Aware Megakernel Polymorphism for Mixture-of-Experts

Makes the newest class of large AI models run significantly faster on the same hardware.

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MixRAG: Mixture-of-Experts Retrieval-Augmented Generation for Textual Graph Understanding and Question Answering

Helps AI answer complex questions by pulling knowledge from many angles at once instead of one.

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Multi-Call Memory in an AI Care Agent for Chronic Care Management Among Older Adults: Retrospective Observational Study

Each memory the AI care agent carried over from a previous call was associated with roughly 2.5 more minutes of

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ManifoldKV: Training-Free KV Cache Compression via Euclidean Outlier Detection

Teaches AI models to keep the right memories — and drop the rest — during long conversations.

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Perfecting Human–AI Interaction at Clinical Scale: Turning Production Signals into Safer, More Human Conversations

What 115 million real patient conversations taught us about making healthcare AI safer and more human.

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HEART: A Unified Benchmark for Assessing Humans and LLMs in Emotional Support Dialogue

The first benchmark measuring whether AI can genuinely emotionally support someone — scored side by side with humans.

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ORION: Teaching Language Models to Reason Efficiently in the Language of Thought

Teaches AI to think in shorthand instead of essays — same answers, dramatically faster.

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TRAJECT-Bench: A Trajectory-Aware Benchmark for Evaluating Agentic Tool Use

Grades AI agents not just on getting the right answer, but on doing the work the right way.

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AI and Nursing: Bridging the Gap for Better Patient Care

Posted by Amy McCarthy DNP, RNC-MNN, NE-BC, CENP Chief Nursing Officer at Hippocratic AI

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AI and Nursing: Bridging the Gap for Better Patient Care

Posted by Amy McCarthy DNP, RNC-MNN, NE-BC, CENP Chief Nursing Officer at Hippocratic AI

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Clinical Case Study: Our AI Agent Breaks Barriers to Care, Driving Improved Health Outcomes

Meenesh Bhimani, MD, MHA - Chief Medical Officer
Amy McCarthy DNP, RNC-MNN, NE-BC, CENP Chief Nursing Officer

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Clinical Case Study: Closing HEDIS Blood Pressure Management Gaps and Preventing Hypertensive Crises

Meenesh Bhimani - Chief Medical Officer

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Supporting Vulnerable Populations: Identifying Risk, Providing Support, and Facilitating Care Connections

Meenesh Bhimani - Chief Medical Officer

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Spotlight Series: Michelle Voisard RN, BSN, CCM – Director of Care Management

Spotlight Series with Co-founder Kim Parikh Interviewing Michelle Voisard - Director of Care Management

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Red Queen: Exposing Latent Multi-Turn Risks in Large Language Models

Shows how attackers trick AI over the course of a conversation — and how to stop them.

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Using a Multilingual AI Care Agent to Reduce Disparities in Colorectal Cancer Screening for Higher Fecal Immunochemical Test Adoption Among Spanish-Speaking Patients: Retrospective Analysis

Spanish-speaking patients called by a multilingual AI care agent opted in to colorectal cancer screening at 2.6 times the rate

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Using a Multilingual AI Care Agent to Reduce Disparities in Colorectal Cancer Screening for Higher Fecal Immunochemical Test Adoption Among Spanish Speaking Patients: Retrospective Analysis

A Spanish-speaking AI caller got 2.6x more patients to say yes to cancer screening — AI closing care gaps, not

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Advancing Nursing Practice Through Artificial Intelligence: Unlocking Its Transformative Impact

AI can extend nursing capacity across decision support, monitoring, and documentation, but only where nurses help shape design and implementation.

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LLM

The Agentification of Software Development

How AI agents are rewriting the way software gets built — a view from our CPO.

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Benchmarks// Safety

Introducing Real-World Evaluation of Large Language Models in Healthcare (RWE-LLM)

A new safety standard: licensed clinicians stress-testing healthcare AI on real outputs at scale.

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Real-World Evaluation of Large Language Models in Healthcare (RWE-LLM): A New Realm of AI Safety & Validation

When 6,234 licensed clinicians reviewed more than 307,000 real patient calls, the rate of clinically correct guidance rose from about

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Real-World Evaluation of Large Language Models in Healthcare (RWE-LLM): A New Realm of AI Safety & Validation

A new safety standard: thousands of licensed clinicians stress-testing healthcare AI before it reaches patients.

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Retrieval-Augmented Generation with Graphs (GraphRAG)

The definitive guide to connecting AI models with structured knowledge — with Meta, Amazon, and Adobe researchers.

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LLM// Safety

Our Safety-Focused Healthcare LLM Is Now Patented

Our core safety architecture — the real-time feedback loop behind every call — is now a granted US patent.

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Closing the Care Gap: AI Care Agent Boosts Colorectal Cancer Screening and Reduces Disparities in Spanish-Speaking Populations

Meenesh Bhimani, MD, MHA - Chief Medical Officer - Hippocratic AI
R. Hal Baker, MD, FACP - SVP &

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Our Safety Focused Healthcare LLM is Now Patented

Vishal Parikh - Chief Product Officer

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LLM// Speech

Closing the Care Gap: AI Care Agent Boosts Colorectal Cancer Screening and Reduces Disparities in Spanish-Speaking Populations

The case study behind our JMIR paper: 2.6x higher cancer-screening opt-in among Spanish speakers.

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LLM// Safety// Speech

Polaris 2.0

Announcing Polaris 2.0: a 3-trillion-parameter constellation that made healthcare AI safer, smarter, and multilingual.

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Polaris 2.0

Posted by Subhabrata Mukherjee, PhD

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LLM

Safety in Action

Real stories of the AI catching problems on calls and getting patients to the right level of care.

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Speech

Paving the Way Towards Improved Empathetic Intelligence — Part 1

Making an AI voice that doesn’t just say the right thing — it sounds like it cares.

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Safety in action

Posted by Dr. Meenesh Bhimani, MD Hippocratic AI

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Clinical Case Study: Empathy in Action

Michelle Voisard - Director of Care Management

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Paving the Way Towards Improved Empathetic Intelligence – Part 1

Shanil Puri - Director, Speech Technologies

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The Human Touch in AI: Dynamic Personalities for Better Care

By Kriti Aggarwal - Staff Applied Scientist

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Improving Patient Engagement Through Personalized Interactions

Akash Chaurasia - Product Research Scientist

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LLM

Empathy in Action: How AI Uses Motivational Interviewing in Patient Care

How the agent uses motivational interviewing and bedside manner to build trust and change behavior.

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Paving the Way Towards Improved Empathetic Intelligence – Part 1

How the agent uses motivational interviewing and bedside manner to build trust and change behavior.

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LLM

Improving Patient Engagement Through Personalized Interactions

Small personal touches — calling at the right time, on the right channel — measurably improve health.

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LLM

The Human Touch in AI: Dynamic Personalities for Better Care

How the agent adapts its personality to each patient — because empathy isn’t one-size-fits-all.

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Hybrid LLM: Cost-Efficient and Quality-Aware Query Routing

Cuts AI costs by sending easy questions to a small model and saving the big model for hard ones.

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Polaris: A Safety-Focused LLM Constellation Architecture for Healthcare

The original blueprint for safe healthcare voice AI: a team of specialist models collaborating and checking each other’s work.

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